5iv7 | pdb_00005iv7

Cryo-electron microscopy structure of the star-shaped, hubless post-attachment T4 baseplate

Loading... Status: waiting for Mol* initialization Structural highlights 5iv7 is a 96 chain structure with sequence from Escherichia virus T4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 6.77Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function BP06_BPT4 Baseplate protein that is part of the baseplate wedge (PubMed:15315755). Involved in the tail assembly. Publication Abstract from PubMed Several systems, including contractile tail bacteriophages, the type VI secretion system and R-type pyocins, use a multiprotein tubular apparatus to attach to and penetrate host cell membranes. This macromolecular machine resembles a stretched, coiled spring (or sheath) wound around a rigid tube with a spike-shaped protein at its tip. A baseplate structure, which is arguably the most complex part of this assembly, relays the contraction signal to the sheath. Here we present the atomic structure of the approximately 6-megadalton bacteriophage T4 baseplate in its pre- and post-host attachment states and explain the events that lead to sheath contraction in atomic detail. We establish the identity and function of a minimal set of components that is conserved in all contractile injection systems and show that the triggering mechanism is universally conserved. Structure of the T4 baseplate and its function in triggering sheath contraction.,Taylor NM, Prokhorov NS, Guerrero-Ferreira RC, Shneider MM, Browning C, Goldie KN, Stahlberg H, Leiman PG Nature. 2016 May 18;533(7603):346-52. doi: 10.1038/nature17971. PMID:27193680 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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