8bo0 | pdb_00008bo0

Solution structure of Lqq4 toxin from Leiurus quinquestriatus quinquestriatus

spinqualitylabelsall models 8bo0 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8bo0 is a 1 chain structure with sequence from Leiurus quinquestriatus quinquestriatus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SCX4_LEIQU Publication Abstract from PubMed Scorpion alpha-toxins (alpha-NaTx) inhibiting the inactivation of voltage-gated sodium channels (Na(v) ) are a well-studied family of small proteins. We previously showed that the structure of alpha-NaTx specificity module responsible for selective Na(v) binding is governed by an interplay between the nest and niche protein motifs. Here, we report the solution structure of the toxin Lqq4 from the venom of the scorpion Leiurus quinquestriatus. Unexpectedly, we find that this toxin presents an ensemble of long-lived structurally distinct states. We unequivocally assign these states to the alternative configurations (cis-trans isomers) of two peptide bonds: V56-P57 and C17-G18; neither of the cis isomers has been described in alpha-NaTx so far. We argue that the native conformational space of alpha-NaTx is wider than assumed previously. A scorpion toxin affecting sodium channels shows double cis-trans isomerism.,Mineev KS, Chernykh MA, Motov VV, Prudnikova DA, Pavlenko DM, Kuzmenkov AI, Peigneur S, Tytgat J, Vassilevski AA FEBS Lett. 2023 Jul 27. doi: 10.1002/1873-3468.14705. PMID:37501371 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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