4kgd | pdb_00004kgd

High-resolution crystal structure of pyruvate oxidase from L. plantarum in complex with phosphate

spinqualitylabelsall models 4kgd, resolution 1.06Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4kgd is a 2 chain structure with sequence from Lactiplantibacillus plantarum JDM1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.06Å Ligands: FAD, GOL, K, MG, PO4, TPP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Carbenes are highly reactive chemical compounds that are exploited as ligands in organometallic chemistry and are powerful organic catalysts. They were postulated to occur as transient intermediates in enzymes, yet their existence in a biological system could never be demonstrated directly. We present spectroscopic and structural data of a thiamin enzyme in a noncovalent complex with substrate, which implicate accumulation of a stable carbene as a major resonance contributor to deprotonated thiamin. Observation of a stable carbene at the active site of a thiamin enzyme.,Meyer D, Neumann P, Ficner R, Tittmann K Nat Chem Biol. 2013 Jun 9. doi: 10.1038/nchembio.1275. PMID:23748673 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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