5wm2 | pdb_00005wm2

Crystal Structure of CahJ in Complex with Salicylic Acid and AMP

spinqualitylabelsall models 5wm2, resolution 1.55Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5wm2 is a 1 chain structure with sequence from Streptomyces gandocaensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.548Å Ligands: ACT, AMP, GOL, SAL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A140DJY3_9ACTN Publication Abstract from PubMed Cahuitamycins are biofilm inhibitors biosynthesized by a convergent NRPS pathway. Previous genetic analysis indicated that a discrete enzyme, CahJ, serves as a gatekeeper for cahuitamycin structural diversification. Herein, the CahJ protein was probed structurally, functionally and through mutasynthesis. This analysis enabled production of a new cahuitamycin congener through targeted precursor incorporation. A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity by the Cahuitamycin Starter Unit Activating Enzyme CahJ.,Sherman DH, Tripathi A, Park SR, Sikkema A, Cho HJ, Wu J, Lee B, Xi C, Smith JL Chembiochem. 2018 May 9. doi: 10.1002/cbic.201800233. PMID:29742306 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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