5wmm | pdb_00005wmm

Crystal structure of an adenylation domain interrupted by a methylation domain (AMA4) from nonribosomal peptide synthetase TioS

spinqualitylabelsall models 5wmm, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5wmm is a 2 chain structure with sequence from Micromonospora sp. ML1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.9Å Ligands: B6G, CA, CL, SAH Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q333U7_9ACTN Publication Abstract from PubMed Interrupted adenylation domains are enigmatic fusions, in which one enzyme is inserted into another to form a highly unusual bifunctional enzyme. We present the first crystal structure of an interrupted adenylation domain that reveals a unique embedded methyltransferase. The structure and functional data provide insight into how these enzymes N-methylate amino acid precursors en route to nonribosomal peptides. Structural basis for backbone N-methylation by an interrupted adenylation domain.,Mori S, Pang AH, Lundy TA, Garzan A, Tsodikov OV, Garneau-Tsodikova S Nat Chem Biol. 2018 Mar 19. pii: 10.1038/s41589-018-0014-7. doi:, 10.1038/s41589-018-0014-7. PMID:29556104 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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