5l7v | pdb_00005l7v

Crystal Structure of BvGH123 with bond transition state analog Galthiazoline.

spinqualitylabelsall models 5l7v, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5l7v is a 2 chain structure with sequence from Phocaeicola vulgatus ATCC 8482. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.3Å Ligands: GNL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A6L2E5_PHOV8 Publication Abstract from PubMed Bacteroides vulgatus is a member of the human microbiota whose abundance is increased in patients with Crohn's disease. We show that a B. vulgatus glycoside hydrolase from the carbohydrate active enzyme family GH123, BvGH123, is an N-acetyl-beta-galactosaminidase that acts with retention of stereochemistry, and, through a 3-D structure in complex with Gal-thiazoline, provide evidence in support of a neighbouring group participation mechanism. Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-beta-galactosaminidase that uses neighbouring group participation.,Roth C, Petricevic M, John A, Goddard-Borger ED, Davies GJ, Williams SJ Chem Commun (Camb). 2016 Sep 25;52(74):11096-9. doi: 10.1039/c6cc04649e. Epub, 2016 Aug 22. PMID:27546776 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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