6pis | pdb_00006pis

Mouse two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure

spinqualitylabelsall models 6pis, resolution 2.77Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6pis is a 6 chain structure with sequence from Cricetulus migratorius and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.77Å Ligands: K Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function KCNK4_MOUSE Voltage-insensitive potassium channel (PubMed:9628867). Channel opening is triggered by mechanical forces that deform the membrane. Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the sensory perception of pain caused by pressure (PubMed:19279663). Plays a role in the perception of pain caused by heat (PubMed:19279663).[UniProtKB:G3V8V5] Publication Abstract from PubMed TRAAK is a membrane tension-activated K(+) channel that has been associated through behavioral studies to mechanical nociception. We used specific monoclonal antibodies in mice to show that TRAAK is localized exclusively to nodes of Ranvier, the action potential propagating elements of myelinated nerve fibers. Approximately 80 percent of myelinated nerve fibers throughout the central and peripheral nervous system contain TRAAK in what is likely an all-nodes or no-nodes per axon fashion. TRAAK is not observed at the axon initial segment where action potentials are first generated. We used polyclonal antibodies, the TRAAK inhibitor RU2 and node clamp amplifiers to demonstrate the presence and functional properties of TRAAK in rat nerve fibers. TRAAK contributes to the 'leak' K(+) current in mammalian nerve fiber conduction by hyperpolarizing the resting membrane potential, thereby increasing Na(+) channel availability for action potential propagation. We speculate on why nodes of Ranvier contain a mechanosensitive K(+) channel. The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier.,Brohawn SG, Wang W, Handler A, Campbell EB, Schwarz JR, MacKinnon R Elife. 2019 Nov 1;8. pii: 50403. doi: 10.7554/eLife.50403. PMID:31674909 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Antibody 3D structures Potassium channel 3D structures 3D structures of non-human antibody

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