8pxs | pdb_00008pxs

Short RNA binding to peptide amyloids

spinqualitylabelsall models 8pxs Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8pxs is a 11 chain structure with sequence from Escherichia coli. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solid-state NMR Ligands: NH2 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Interactions between RNA and proteins are the cornerstone of many important biological processes from transcription and translation to gene regulation, yet little is known about the ancient origin of said interactions. We hypothesized that peptide amyloids played a role in the origin of life and that their repetitive structure lends itself to building interfaces with other polymers through avidity. Here, we report that short RNA with a minimum length of three nucleotides binds in a sequence-dependent manner to peptide amyloids. The 3'-5' linked RNA backbone appears to be well-suited to support these interactions, with the phosphodiester backbone and nucleobases both contributing to the affinity. Sequence-specific RNA-peptide interactions of the kind identified here may provide a path to understanding one of the great mysteries rooted in the origin of life: the origin of the genetic code. An Analysis of Nucleotide-Amyloid Interactions Reveals Selective Binding to Codon-Sized RNA.,Rout SK, Cadalbert R, Schroder N, Wang J, Zehnder J, Gampp O, Wiegand T, Guntert P, Klingler D, Kreutz C, Knorlein A, Hall J, Greenwald J, Riek R J Am Chem Soc. 2023 Oct 11;145(40):21915-21924. doi: 10.1021/jacs.3c06287. Epub , 2023 Oct 2. PMID:37782045 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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