7u8c | pdb_00007u8c

Crystal structure of Mesothelin C-terminal peptide-MORAb 15B6 FAB complex

spinqualitylabelsall models 7u8c, resolution 1.74Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7u8c is a 3 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.74Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease MSLN_HUMAN Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. Function MSLN_HUMAN Membrane-anchored forms may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. Publication Abstract from PubMed SignificanceMesothelin (MSLN) is a cell-surface protein that is a popular target for antibody-based therapies. We have identified shed MSLN as a major obstacle to successful antibody therapies and prepared a monoclonal antibody that inhibits shedding and makes very active CAR T cells whose activity is not blocked by shed MSLN and merits further preclinical development. Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin.,Liu X, Onda M, Watson N, Hassan R, Ho M, Bera TK, Wei J, Chakraborty A, Beers R, Zhou Q, Shajahan A, Azadi P, Zhan J, Xia D, Pastan I Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2202439119. doi: , 10.1073/pnas.2202439119. Epub 2022 May 5. PMID:35512094 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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