4ysh | pdb_00004ysh

Crystal structure of glycine oxidase from Geobacillus kaustophilus

spinqualitylabelsall models 4ysh, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ysh is a 2 chain structure with sequence from Geobacillus kaustophilus HTA426. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.2Å Ligands: CL, FAD, GLY, IPA, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function GLYOX_GEOKA Catalyzes the FAD-dependent oxidative deamination of various amines and D-amino acids to yield the corresponding alpha-keto acids, ammonia/amine, and hydrogen peroxide. Oxidizes glycine, sarcosine (N-methylglycine), N-ethylglycine, D-proline, D-alanine, glycine-ethyl ester, and some other D-amino acids. Does not act on L-proline (PubMed:17894345). Is essential for thiamine biosynthesis since the oxidation of glycine catalyzed by ThiO generates the glycine imine intermediate (dehydroglycine) required for the biosynthesis of the thiazole ring of thiamine pyrophosphate (By similarity).[UniProtKB:O31616]

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