2l2f | pdb_00002l2f

NMR Structure of GzCVNH (Gibberella zeae CVNH)

spinqualitylabelsall models 2l2f Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2l2f is a 1 chain structure with sequence from Fusarium graminearum. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function I1RM03_GIBZE Publication Abstract from PubMed Members of the cyanovirin-N homolog (CVNH) lectin family are found in bacteria, fungi and plants. As part of our ongoing work on CVNH structure-function studies, we determined the high-resolution NMR solution structure of the homolog from the wheat head blight disease causing ascomycetous fungus Gibberella zeae (or Fusarium graminearum), hereafter called GzCVNH. Like cyanovirin-N (CV-N), GzCVNH comprises two tandem sequence repeats and the protein sequence exhibits 30% identity with CV-N. The overall structure is similar to those of other members of the CVNH family, with the conserved pseudo-symmetric halves of the structure, domains A and B, closely resembling recently determined structures of Tuber borchii, Neurospora crassa, and Ceratopteris richardii CVNH proteins. Although GzCVNH exhibits a similar glycan recognition profile to CV-N and specifically binds to Manalpha(1-2)Manalpha, its weak carbohydrate binding affinity to only one binding site is insufficient for conferring anti-HIV activity. Proteins 2011; (c) 2011 Wiley-Liss, Inc. NMR solution structure of a cyanovirin homolog from wheat head blight fungus.,Matei E, Louis JM, Jee J, Gronenborn AM Proteins. 2011 Jan 18. doi: 10.1002/prot.22981. PMID:21365681 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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