3sbn | pdb_00003sbn

trichovirin I-4A in polar environment at 0.9 Angstroem

spinqualitylabelsall models 3sbn, resolution 0.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3sbn is a 2 chain structure with sequence from Trichoderma viride. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 0.9Å Ligands: ACE, AIB, CCN, DCL, MOH, PRD_000828 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The first crystal structure of a member of peptaibol antibiotic subfamily 4, trichovirin I-4A (14 residues), has been determined by direct methods and refined at atomic resolution. The monoclinic unit cell has two molecules in the asymmetric unit. Both molecules assume a 3(10) right-handed helical conformation and are significantly bent. The molecules pack loosely along the crystallographic twofold axis, forming two large tunnels between symmetry-related molecules in which no ordered solvent could be located. Carbonyl O atoms which are not involved in intramolecular hydrogen bonding participate in close van der Waals interactions with apolar groups. The necessary amphipathicity for biological activity of peptaibols is not realised in the crystal structure. Hence, a structural change of trichovirin to an alpha-helical conformation is proposed for membrane integration and efficient water/ion transportation across the lipid bilayer. Four complete turns of a curved 3(10)-helix at atomic resolution: the crystal structure of the peptaibol trichovirin I-4A in a polar environment suggests a transition to alpha-helix for membrane function.,Gessmann R, Axford D, Owen RL, Bruckner H, Petratos K Acta Crystallogr D Biol Crystallogr. 2012 Feb;68(Pt 2):109-16. Epub 2012, Jan 6. PMID:22281739 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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