Sorting nexin

spinqualitylabelsall models Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry 3dyt) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Sorting nexins (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association. The PX domain contains a phospholipid-binding motif. SNX 1 regulates trafficking in the endosome compartment. SNX 3 regulates neurite formation. SNX 5 regulates retrograde trafficking of transmembrane cargo receptors. SNX 7 regulates the survival of cells in embryonic liver. SNX 9 has a role in endocytosis. SNX 10 induces giant vacuoles in mammalian cells. SNX 11and SNX 17 regulate lysosomal degradation of plasma membrane. SNX 12 regulates BACE1-mediated APP processing . SNX 14 has a role in maintaining normal neuronal excitability. SNX 16 has a role in protein transport from early to late endosomes. SNX 22, SNX 24, SNX 25 and SNX 32 may have a role in intracellular trafficking. SNX 27 modulates synaptic plasticity. SNX 33 induces micronucleated phenotype and actin polymerization. Relevance SNX 2 is a potential marker of hyperfunctioning thyroid disorders. 3D structures of sorting nexin Sorting nexin 3D structures

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