Spermidine synthase 3D structures

3D structures of spermidine synthase

Updated on 22-November-2023

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• Spermidine synthase
  • 2o05, 2o06, 2o07, 2o0l – SPS – human
    
  • 2b2c – SPS – Caenorhabditis elegans
    
  • 1xj5, 2q41, 6o63 – AtSPS 1 – Arabidopsis thaliana
    
  • 6o64 – AtSPS 2
    
  • 1inl – TmSPS – Thermotoga maritima
    
  • 1mjf – SPS – Pyrococcus furiosus
    
  • 2e5w, 2zsu - SPS – Pyrococcus horikishii
    
  • 1iy9 – SPS – Bacillus subtilis
    
  • 2cmg, 2cmh – SPS – Helicobacter pylori
    
  • 2pss – PfSPS – Plasmodium falciparum
    
  • 3o4f – SPS – Escherichia coli
    
  • 3bwb - TcSPS – Trypanosoma cruzi
    
  • 8iyi - SPS – Kluyveromyces lactis
    
• Binary complexes of spermidine synthase
  • 3rw9 - hSPS + SAH
    
  • 6o65 – AtSPS 1 + SAM
    
  • 1jq3 – TmSPS + transition state analog
    
  • 2hte, 2pt6 - PfSPS + methylthioadenosine
    
  • 2i7c - PfSPS + transition state analog
    
  • 2pwp - PfSPS + spermidine
    
  • 3b7p - PfSPS + spermine
    
  • 6i1n, 6hy1 – PfSPS + cyclohexane derivative
    
  • 3bwc - TcSPS + SAM
    
  • 5y4p– TcSPS + imidazole derivative
    
  • 5y4q– TcSPS + quinoline derivative
    
  • 3anx – TtSPS + methylthioadenosine – Thermus thermophilus
    
  • 5x0z – HpSPS + Flim
    
  • 7xig – PcSPS + MTA – Pyrobaculum calidifontis
    
• Ternary complexes of spermidine synthase
  • 3c6k, 4cxm, 4uoe - hSPS + methylthioadenosine + spermidine
    
  • 3c6m - hSPS + methylthioadenosine + spermine
    
  • 2pt6, 3rie, 4bp3, 4bp1 - PfSPS + inhibitor + methylthioadenosine
    
  • 2pt9 - PfSPS + inhibitor + SAM derivative
    
  • 4cwa, 5b1s - PfSPS + inhibitor + ethanol derivative
    
  • 4yv0, 4yv1, 4yv2, 4yuv, 4yuw, 4yux, 4yuy, 4yuz - TcSPS + inhibitor + SAM derivative
    
  • 6qmm - SPS + putrescine + spermidine – Synchococcus elongatus
    
  • 7xii – PcSPS + MTA + agmatine derivative
    
  • 7xih – PcSPS + MTA + spermidine
    
  • 7xif – PcSPS + MTA + spermidine + thermospermine
    
• N(4) – Bis(aminopropyl) spermidine synthase or branched-chain polyamine synthase
  • 5xnf – TkBPSA – Thermococcus kodakarensis
    
  • 5xnh – TkBPSA + spermidine
    
  • 5xnc, 6j26 – TkBPSA + N4-aminopropylspermidine + methylthioadenosine
    
  • 6j27 – TtBPSA + N4-aminopropylspermidine + methylthioadenosine
    
  • 6j28 – TtBPSA (mutant) + N4-aminopropylspermidine + methylthioadenosine
    

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Michal Harel