5z2q | pdb_00005z2q

Vgll1-TEAD4 core complex

spinqualitylabelsall models 5z2q, resolution 2.74Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5z2q is a 4 chain structure with sequence from Mus musculus. This structure supersedes the now removed PDB entry 4eaz. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.74Å Ligands: PO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function VGLL1_MOUSE May act as a specific coactivator for the mammalian TEFs (By similarity). Publication Abstract from PubMed The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4, the mammalian equivalent of the Drosophila Vestigial and Scalloped, respectively, is determined in this study. Remarkably, Vgll1 interacts with TEAD in a manner similar to the transcription coactivators, as well as oncogenes YAP and TAZ, despite having a varied primary sequence. Vgll1-TEAD complex upregulates the expression of IGFBP-5, a proliferation-promoting gene, and facilitates anchorage-independent cell proliferation. The YAP/TAZ-TEAD complex also upregulates several other proliferation-promoting genes and also promotes anchorage-independent cell proliferation. Given its structural and functional similarity to YAP/TAZ, Vgll1 has the potential to promote cancer progression. Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes.,Pobbati AV, Chan SW, Lee I, Song H, Hong W Structure. 2012 Jul 3;20(7):1135-40. Epub 2012 May 24. PMID:22632831 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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