2mbd | pdb_00002mbd

Lasiocepsin

spinqualitylabelsall models 2mbd Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2mbd is a 1 chain structure with sequence from Lasioglossum laticeps. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function W5IDB3_LASLA Publication Abstract from PubMed Lasiocepsin is a unique 27-residue antimicrobial peptide, isolated from Lasioglossum laticeps (wild bee) venom, with substantial antibacterial and antifungal activity. It adopts a welldefined structure consisting of two alpha-helices linked by a structured loop. Its basic residues form two distinct positively charged regions on the surface whereas aliphatic side chains contribute to solvent-accessible hydrophobic areas, thus emphasising the amphipathic character of the molecule. Lasiocepsin structurally belongs to the ShK family and shows a strong preference for anionic phospholipids; this is further augmented by increasing concentrations of cardiolipin, such as those found at the poles of bacterial cells. The membrane-permeabilising activity of the peptide is not limited to outer membranes of Gram-negative bacteria. The peptide interacts with phospholipids initially through its N terminus, and its degree of penetration is strongly dependent on the presence of cardiolipin. Structural Basis for Antimicrobial Activity of Lasiocepsin.,Monincova L, Budesinsky M, Cujova S, Cerovsky V, Veverka V Chembiochem. 2013 Dec 12. doi: 10.1002/cbic.201300509. PMID:24339323 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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