1fyg | pdb_00001fyg

Solution structure of omega conotoxin SO3 determined by 1H-NMR

spinqualitylabelsall models 1fyg Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1fyg is a 1 chain structure with sequence from Conus striatus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function O16O3_CONST Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This peptide selectively targets Cav2.2/CACNA1B (IC(50)=160 nM) voltage-gated calcium channels (PubMed:26344359). When tested in mammals, this toxin displays an analgesic potency similar to MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects (tremor, diminution of spontaneous locomotor activity and bad coordinated locomotion) compared with identical dosages of MVIIA injected intrathecally.

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