1k2k | pdb_00001k2k

NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)2

spinqualitylabelsall models 1k2k Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1k2k is a 2 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Solution structures and base pair stacking of a self- complementary DNA hexamer d(CGTACG)(2) have been studied at 5, 10 and 15 degrees C, respectively. The stacking interactions among the center base pair steps of the DNA duplex are found to improve when the terminal base pairs became less stable due to end fraying. A new structural quantity, the stacking sum (Sigma(s)), is introduced to indicate small changes in the stacking overlaps between base pairs. The improvements in the stacking overlaps to maintain the double helical conformation are probably the cause for the observed temperature dependent structural changes in double helical DNA molecule. A detailed analysis of the helical parameters, backbone torsion angles, base orientations and sugar conformations of these structures has been performed. Low temperature solution structures and base pair stacking of double helical d(CGTACG)(2).,Lam SL, Ip LN J Biomol Struct Dyn. 2002 Apr;19(5):907-17. PMID:11922844 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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