Structural highlights
8oru is a 4 chain structure with sequence from Methanothermus fervidus DSM 2088. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.23Å |
| Ligands: | ADP, DG2, EDO, MG, PO4 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
CPGS_METFV Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP. It is also able to catalyze the hydrolysis of cDPG but with significant slower rates (8-10 times). May be involved in thermoadaptation.[1] [2]
References
- ↑ Lehmacher A, Vogt AB, Hensel R. Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus. FEBS Lett. 1990 Oct 15;272(1-2):94-8. PMID:2226838 doi:10.1016/0014-5793(90)80456-s
- ↑ Matussek K, Moritz P, Brunner N, Eckerskorn C, Hensel R. Cloning, sequencing, and expression of the gene encoding cyclic 2, 3-diphosphoglycerate synthetase, the key enzyme of cyclic 2, 3-diphosphoglycerate metabolism in Methanothermus fervidus. J Bacteriol. 1998 Nov;180(22):5997-6004. PMID:9811660 doi:10.1128/JB.180.22.5997-6004.1998
