2b9z | pdb_00002b9z

Solution structure of FHV B2, a viral suppressor of RNAi

spinqualitylabelsall models 2b9z Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2b9z is a 2 chain structure with sequence from Flock House virus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B2_FHV Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response. Publication Abstract from PubMed We report the structure of the flock house virus B2 protein, a potent suppressor of RNA interference (RNAi) in animals and plants. The B2 protein is a homodimer in solution and contains three alpha-helices per monomer. Chemical shift perturbation shows that an antiparallel arrangement of helices (alpha2/alpha2') forms an elongated binding interface with double-stranded RNA (dsRNA). This implies a novel mode of dsRNA recognition and provides insights into the mechanism of RNAi suppression by B2. The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition.,Lingel A, Simon B, Izaurralde E, Sattler M EMBO Rep. 2005 Dec;6(12):1149-55. PMID:16270100 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Flock house virus protein B2 P19 Suppression of RNA Silencing by Viruses Tomato aspermy virus protein 2b Suppression of RNA Silencing

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