8ter | pdb_00008ter

Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber

spinqualitylabelsall models 8ter, resolution 2.59Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8ter is a 20 chain structure with sequence from Homo sapiens and Purpureocillium lilacinum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.59Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease TFG_HUMAN Autosomal recessive spastic paraplegia type 57;Extraskeletal myxoid chondrosarcoma;Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation;Hereditary motor and sensory neuropathy, Okinawa type;Differentiated thyroid carcinoma. A chromosomal aberration involving TFG is found in papillary thyroid carcinomas (PTCs). Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Function TFG_HUMAN Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). A0A2U3DNX3_PURLI

Proteopedia Page Contributors and Editors (what is this?)

OCA