2yeo | pdb_00002yeo

A39L mutation of scorpion toxin lqh-alpha-it

spinqualitylabelsall models 2yeo, resolution 1.08Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2yeo is a 1 chain structure with sequence from Leiurus quinquestriatus hebraeus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.08Å Ligands: CL, DR0, DR8, EDO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SCXA_LEIHE Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice.

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