8i7q | pdb_00008i7q

Cobalt and Calcium coordinated Concanavalin A at pH 7.4 from Canavalia ensiformis

spinqualitylabelsall models 8i7q, resolution 2.83Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8i7q is a 1 chain structure with sequence from Canavalia ensiformis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.83Å Ligands: CA, CO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Concanavalin A (ConA) has an intrinsic binding affinity to carbohydrates. Here, we obtained Co(2+)-Ca(2+)-ConA (2.83 A, PDB: 8I7Q) via X-ray crystallography by substituting native ConA (Mn(2+)-Ca(2+)); it has binding selectivity for high-mannose N-glycan similar to native ConA. Our findings may thus inform antiviral reagent design. Selective interactions of Co(2+)-Ca(2+)-concanavalin A with high mannose N-glycans.,Hwang Y, Jeong JH, Lee DH, Lee SJ Dalton Trans. 2023 Dec 12. doi: 10.1039/d3dt03575a. PMID:38086668 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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