2rrr | pdb_00002rrr

DNA oligomer containing ethylene cross-linked cyclic 2'-deoxyuridylate dimer

spinqualitylabelsall models 2rrr Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2rrr is a 2 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed High Mobility Group Box 1 (HMGB1) protein, a potential therapeutic target, binds bent DNAs structure-specifically. Here we report on a crucial structural feature of the bent DNA required for strong binding to HMGB1. NMR structures of two bent DNA oligomers, only one of which binds strongly to HMGB1, revealed that the presence of a pocket structure on the minor groove is crucial for strong binding through penetration of a phenylalanine residue. Structural feature of bent DNA recognized by HMGB1.,Furuita K, Murata S, Jee JG, Ichikawa S, Matsuda A, Kojima C J Am Chem Soc. 2011 Apr 20;133(15):5788-90. Epub 2011 Mar 28. PMID:21443191 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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