5ov2 | pdb_00005ov2

2'F-ANA-G modified quadruplex with a flipped tetrad

spinqualitylabelsall models 5ov2 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5ov2 is a 1 chain structure with sequence from Synthetic construct. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Ligands: GFL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed A G-quadruplex adopting a (3 + 1)-hybrid structure was substituted at its 5'-tetrad by 2'-deoxy-2'-fluoro-arabinoguanosine (FaraG) analogs. Incorporation of anti-favoring FaraG at syn-positions of the 5'-outer tetrad induced a reversal of the tetrad polarity without noticeably compromising the quadruplex stability. This conformational change is shown to be promoted by nonconventional C-H...F hydrogen bonds acting within the anti-FaraG residues. Nonconventional C-H...F Hydrogen Bonds Support a Tetrad Flip in Modified G-Quadruplexes.,Dickerhoff J, Weisz K J Phys Chem Lett. 2017 Oct 6:5148-5152. doi: 10.1021/acs.jpclett.7b02428. PMID:28976755 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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