4wfv | pdb_00004wfv

Bovine allergen Bos d 2 in the monoclinic space group C2.

spinqualitylabelsall models 4wfv, resolution 1.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4wfv is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.4Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ALL2_BOVIN Probable pheromone carrier. Publication Abstract from PubMed Lipocalins are one of the most important groups of inhalant animal allergens. The analysis of structural features of these proteins is important to get insights into their allergenicity. We have determined two different dimeric crystal structures for bovine dander lipocalin Bos d 2, which was earlier described as a monomeric allergen. The crystal structure analysis of all other determined lipocalin allergens also revealed oligomeric structures which broadly utilize inherent structural features of the beta-sheet in dimer formation. According to the moderate size of monomer-monomer interfaces, most of these dimers would be transient in solution. Native mass spectrometry was employed to characterize quantitatively transient dimerization of two lipocalin allergens, Bos d 2 and Bos d 5, in solution. Dimerization of lipocalin allergens.,Niemi MH, Rytkonen-Nissinen M, Miettinen I, Janis J, Virtanen T, Rouvinen J Sci Rep. 2015 Sep 8;5:13841. doi: 10.1038/srep13841. PMID:26346541 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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