4xfw | pdb_00004xfw

Crystal structure of the monoclinic form of alpha-carbonic anhydrase from the human pathogen Helicobacter pylori

spinqualitylabelsall models 4xfw, resolution 1.52Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4xfw is a 2 chain structure with sequence from Helicobacter pylori G27. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.517Å Ligands: ACY, CL, SO4, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B5Z8I0_HELPG Publication Abstract from PubMed The crystal structure of alpha-carbonic anhydrase, an enzyme present in the periplasm of Helicobacter pylori, a bacterium that affects humans and that is responsible for several gastric pathologies, is described. Two enzyme monomers are present in the asymmetric unit of the monoclinic space group P21, forming a dimer in the crystal. Despite the similarity of the enzyme structure to those of orthologues from other species, the H. pylori protein has adopted peculiar features in order to allow the bacterium to survive in the difficult environment of the human stomach. In particular, the crystal structure shows how the bacterium has corrected for the mutation of an essential amino acid important for catalysis using a negative ion from the medium and how it localizes close to the inner membrane in the periplasm. Since carbonic anhydrase is essential for the bacterial colonization of the host, it is a potential target for antibiotic drugs. The definition of the shape of the active-site entrance and cavity constitutes a basis for the design of specific inhibitors. Structure of alpha-carbonic anhydrase from the human pathogen Helicobacter pylori.,Compostella ME, Berto P, Vallese F, Zanotti G Acta Crystallogr F Struct Biol Commun. 2015 Aug 1;71(Pt 8):1005-11. doi:, 10.1107/S2053230X15010407. Epub 2015 Jul 28. PMID:26249690 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Carbonic anhydrase 3D structures

Proteopedia Page Contributors and Editors (what is this?)

OCA