5ck5 | pdb_00005ck5

Signal recognition particle receptor SRb-GDP-Mg from Chaetomium thermophilum

spinqualitylabelsall models 5ck5, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5ck5 is a 4 chain structure with sequence from Chaetomium thermophilum var. thermophilum DSM 1495. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.4Å Ligands: GDP, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function G0S401_CHATD Publication Abstract from PubMed G proteins of the Ras-family of small GTPases trace the evolution of eukaryotes. The earliest branching involves the closely related Arf, Sar1, and SRbeta GTPases associated with secretory membranes. SRbeta is an integral membrane component of the signal recognition particle (SRP) receptor that targets ribosome-nascent chain complexes to the ER. How SRbeta integrates into the regulation of SRP-dependent membrane protein biogenesis is not known. Here we show that SRbeta-GTP interacts with ribosomes only in presence of SRalpha and present crystal structures of SRbeta in complex with the SRX domain of SRalpha in the GTP-bound state at 3.2 A, and of GDP- and GDP.Mg2+-bound SRbeta at 1.9 A and 2.4 A, respectively. We define the GTPase switch cycle of SRbeta and identify specific differences to the Arf and Sar1 families with implications for GTPase regulation. Our data allow a better integration of SRbeta into the scheme of protein targeting. Structure and Switch Cycle of SRbeta as Ancestral Eukaryotic GTPase Associated with Secretory Membranes.,Jadhav B, Wild K, Pool MR, Sinning I Structure. 2015 Aug 18. pii: S0969-2126(15)00292-0. doi:, 10.1016/j.str.2015.07.010. PMID:26299945 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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