5d55 | pdb_00005d55

Crystal structure of the E. coli Hda pilus minor tip subunit, HdaB

spinqualitylabelsall models 5d55, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5d55 is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2Å Ligands: FLC, IOD Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B3V224_ECOLX Q08JP6_ECOLX Publication Abstract from PubMed Enteroaggregative Escherichia coli is the primary cause of pediatric diarrhea in developing countries. They utilize aggregative adherence fimbriae (AAFs) to promote initial adherence to the host intestinal mucosa, promote the formation of biofilms, and mediate host invasion. Five AAFs have been identified to date and AAF/IV is amongst the most prevalent found in clinical isolates. Here we present the X-ray crystal structure of the AAF/IV tip protein HdaB at 2.0 A resolution. It shares high structural homology with members of the Afa/Dr superfamily of fimbriae, which are involved in host invasion. We highlight surface exposed residues that share sequence homology and propose that these may function in invasion and also non-conserved regions that could mediate HdaB specific adhesive functions. Crystal structure and analysis of HdaB: The enteroaggregative Escherichia coli AAF/IV pilus tip protein.,Lee WC, Matthews S, Garnett JA Protein Sci. 2016 Jul 12. doi: 10.1002/pro.2982. PMID:27400770 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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