7xw9 | pdb_00007xw9

Cryo-EM structure of the TRH-bound human TRHR-Gq complex

spinqualitylabelsall models 7xw9, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7xw9 is a 6 chain structure with sequence from Bos taurus, Homo sapiens, Rattus norvegicus and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.7Å Ligands: NH2, PCA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease TRFR_HUMAN Resistance to thyrotropin-releasing hormone syndrome. The disease is caused by variants affecting the gene represented in this entry. Function TRFR_HUMAN Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

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