6qup | pdb_00006qup

Structural signatures in EPR3 define a unique class of plant carbohydrate receptors

spinqualitylabelsall models 6qup, resolution 1.87Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6qup is a 2 chain structure with sequence from Lama glama and Lotus japonicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.871Å Ligands: EDO, IPA, NAG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function D3KU53_LOTJA Publication Abstract from PubMed Receptor-mediated perception of surface-exposed carbohydrates like lipo- and exo-polysaccharides (EPS) is important for non-self recognition and responses to microbial associated molecular patterns in mammals and plants. In legumes, EPS are monitored and can either block or promote symbiosis with rhizobia depending on their molecular composition. To establish a deeper understanding of receptors involved in EPS recognition, we determined the structure of the Lotus japonicus (Lotus) exopolysaccharide receptor 3 (EPR3) ectodomain. EPR3 forms a compact structure built of three putative carbohydrate-binding modules (M1, M2 and LysM3). M1 and M2 have unique betaalphabetabeta and betaalphabeta folds that have not previously been observed in carbohydrate binding proteins, while LysM3 has a canonical betaalphaalphabeta fold. We demonstrate that this configuration is a structural signature for a ubiquitous class of receptors in the plant kingdom. We show that EPR3 is promiscuous, suggesting that plants can monitor complex microbial communities though this class of receptors. Structural signatures in EPR3 define a unique class of plant carbohydrate receptors.,Wong JEMM, Gysel K, Birkefeldt TG, Vinther M, Muszynski A, Azadi P, Laursen NS, Sullivan JT, Ronson CW, Stougaard J, Andersen KR Nat Commun. 2020 Jul 30;11(1):3797. doi: 10.1038/s41467-020-17568-9. PMID:32732998 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Antibody 3D structures

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