6rjm | pdb_00006rjm

Complex structure of virulence factor SghA and its hydrolysis product glucose

spinqualitylabelsall models 6rjm, resolution 2.11Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6rjm is a 2 chain structure with sequence from Agrobacterium tumefaciens A6. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.112Å Ligands: GLC Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A2I4PGZ0_RHIRD Publication Abstract from PubMed It is highly intriguing how bacterial pathogens can quickly shut down energy-costly infection machinery once successful infection is established. This study depicts that mutation of repressor SghR increases the expression of hydrolase SghA in Agrobacterium tumefaciens, which releases plant defense signal salicylic acid (SA) from its storage form SA beta-glucoside (SAG). Addition of SA substantially reduces gene expression of bacterial virulence. Bacterial vir genes and sghA are differentially transcribed at early and later infection stages, respectively. Plant metabolite sucrose is a signal ligand that inactivates SghR and consequently induces sghA expression. Disruption of sghA leads to increased vir expression in planta and enhances tumor formation whereas mutation of sghR decreases vir expression and tumor formation. These results depict a remarkable mechanism by which A. tumefaciens taps on the reserved pool of plant signal SA to reprogram its virulence upon establishment of infection. Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals.,Wang C, Ye F, Chang C, Liu X, Wang J, Wang J, Yan XF, Fu Q, Zhou J, Chen S, Gao YG, Zhang LH Proc Natl Acad Sci U S A. 2019 Oct 11. pii: 1903695116. doi:, 10.1073/pnas.1903695116. PMID:31604827 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Beta-glucosidase 3D structures

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