6tkz | pdb_00006tkz

Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42

spinqualitylabelsall models 6tkz, resolution 2.64Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6tkz is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.64Å Ligands: GDP, GOL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function DOC10_HUMAN Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.[UniProtKB:Q8BZN6] See Also Dedicator of cytokinesis protein 3D structures GTP-binding protein 3D structures

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