3jbq | pdb_00003jbq

Domain Organization and Conformational Plasticity of the G Protein Effector, PDE6

Loading... Status: waiting for Mol* initialization Structural highlights 3jbq is a 12 chain structure with sequence from Bos taurus and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 11Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PDE5A_BOVIN Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:8530505). Specifically regulates nitric-oxide-generated cGMP (By similarity).[UniProtKB:O76074] PDE6C_BOVIN As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP.[UniProtKB:P51160]

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