3jcl | pdb_00003jcl

Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

Loading... Status: waiting for Mol* initialization Structural highlights 3jcl is a 3 chain structure with sequence from Murine hepatitis virus strain A59. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SPIKE_CVMA5 S1 attaches the virion to the cell membrane by interacting with murine CEACAM1, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Presumably interacts with target cell lipid raft after cell attachment. See Also Sandbox 3001 Spike protein 3D structures

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