1seb | pdb_00001seb
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COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB
Overview
The structure of a bacterial superantigen, Staphylococcus aureus, enterotoxin B, bound to a human class II histocompatibility complex, molecule (HLA-DR1) has been determined by X-ray crystallography. The, superantigen binds as an intact protein outside the conventional peptide, antigen-binding site of the class II major histocompatibility complex, (MHC) molecule. No large conformational changes occur upon complex, formation in either the DR1 or the enterotoxin B molecules. The structure, of the complex helps explain how different class II molecules and, superantigens associate and suggests a model for ternary complex formation, with the T-cell antigen receptor (TCR), in which unconventional TCR-MHC, contacts are possible.
About this Structure
1SEB is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen., Jardetzky TS, Brown JH, Gorga JC, Stern LJ, Urban RG, Chi YI, Stauffacher C, Strominger JL, Wiley DC, Nature. 1994 Apr 21;368(6473):711-8. PMID:8152483
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