3j5s | pdb_00003j5s

EttA binds to ribosome exit site and regulates translation by restricting ribosome and tRNA dynamics

Loading... Status: waiting for Mol* initialization Structural highlights 3j5s is a 8 chain structure with sequence from Escherichia coli and Escherichia coli str. K-12 substr. MG1655. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 7.5Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ETTA_ECOLI A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. Stimulates dipeptide bond synthesis in the presence of ATP (cell in high energy state), but inhibits dipeptide synthesis in the presence of ADP (cell in low energy state), and thus may control translation in response to changing ATP levels (including during stationary phase). Following ATP hydrolysis is probably released allowing the ribosome to enter the elongation phase. ATPase activity is stimulated in the presence of ribosomes. Its specificity for the IC may be conferred by its recognition of features unique to tRNA(fMet). See Also Ribosomal protein L1 Ribosomal protein L33 Ribosomal protein L5 Transfer RNA (tRNA)

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