8ik4 | pdb_00008ik4

Structure of DNA binding domain of McrBC endonuclease bound to hemimethylated DNA: L68F mutant

spinqualitylabelsall models 8ik4, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8ik4 is a 4 chain structure with sequence from DNA molecule and Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.1Å Ligands: 5CM, BTB Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MCRB_ECOLI Recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines) produced by a broad range of DNA methylases and appears to act against 5-methylcytosine preceded by a purine residue. Binds to DNA containing methylated cytosines; also binds to GTP. Isoform 33 kDa is less active than isoform 51 kDa and may play a role in regulating the activity of isoform 51 kDa by competing with it in DNA and protein binding abilities.

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