| Structural highlights
3sh3 is a 1 chain structure with sequence from Macropsychanthus wilsonii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Method: | X-ray diffraction, Resolution 2.3Å |
| Ligands: | A3B, CA, CL, MN, XMM |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
LECA_MACWI D-mannose/D-glucose-binding lectin with hemagglutinating activity towards rabbit and human erythrocytes. In rats, elicits an acute inflammatory response by inducing neutrophil migration and induces dose-dependent paw edema.[1] [2]
References
- ↑ Rangel TB, Assreuy AM, Pires Ade F, Carvalho AU, Benevides RG, Simoes Rda C, Silva HC, Bezerra MJ, Nascimento AS, Nascimento KS, Nagano CS, Sampaio AH, Delatorre P, Rocha BA, Fernandes PM, Cavada BS. Crystallization and characterization of an inflammatory lectin purified from the seeds of Dioclea wilsonii. Molecules. 2011 Jun 20;16(6):5087-103. doi: 10.3390/molecules16065087. PMID:21694673 doi:https://dx.doi.org/10.3390/molecules16065087
- ↑ Rangel TB, Rocha BA, Bezerra GA, Assreuy AM, Pires AD, do Nascimento AS, Bezerra MJ, do Nascimento KS, Nagano CS, Sampaio AH, Gruber K, Delatorre P, Fernandes PM, Cavada BS. Crystal structure of a pro-inflammatory lectin from the seeds of Dioclea wilsonii Standl. Biochimie. 2011 Sep 10. PMID:21924319 doi:10.1016/j.biochi.2011.09.001
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