| Structural highlights
4k1z is a 4 chain structure with sequence from Canavalia boliviana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Method: | X-ray diffraction, Resolution 2.3Å |
| Ligands: | CA, CD, CL, MAN, MMA, MN |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
LECA_CANBL D-mannose/D-glucose-binding lectin (PubMed:24865454). Has anti-inflammatory activity in animal models when applied intravenously (PubMed:24865454). Has antinociceptive activity in mice when applied intravenously (PubMed:19705102).[1] [2]
References
- ↑ Figueiredo JG, da Silveira Bitencourt F, Beserra IG, Teixeira CS, Luz PB, Bezerra EH, Mota MR, Assreuy AM, de Queiroz Cunha F, Cavada BS, de Alencar NM. Antinociceptive activity and toxicology of the lectin from Canavalia boliviana seeds in mice. Naunyn Schmiedebergs Arch Pharmacol. 2009 Nov;380(5):407-14. doi: , 10.1007/s00210-009-0448-2. Epub 2009 Aug 25. PMID:19705102 doi:https://dx.doi.org/10.1007/s00210-009-0448-2
- ↑ Bezerra GA, Viertlmayr R, Moura TR, Delatorre P, Rocha BA, do Nascimento KS, Figueiredo JG, Bezerra IG, Teixeira CS, Simoes RC, Nagano CS, de Alencar NM, Gruber K, Cavada BS. Structural Studies of an Anti-Inflammatory Lectin from Canavalia boliviana Seeds in Complex with Dimannosides. PLoS One. 2014 May 27;9(5):e97015. doi: 10.1371/journal.pone.0097015. eCollection, 2014. PMID:24865454 doi:https://dx.doi.org/10.1371/journal.pone.0097015
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