4kha | pdb_00004kha

Structural basis of histone H2A-H2B recognition by the essential chaperone FACT

spinqualitylabelsall models 4kha, resolution 2.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4kha is a 2 chain structure with sequence from Chaetomium thermophilum var. thermophilum DSM 1495 and Xenopus laevis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.35Å Ligands: CL, TRS Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function H2B11_XENLA Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.G0SDN1_CHATD

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