4kxt | pdb_00004kxt

Structure of human ARGONAUTE1 in complex with guide RNA

spinqualitylabelsall models 4kxt, resolution 2.29Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4kxt is a 2 chain structure with sequence from Homo sapiens and Spodoptera frugiperda. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.294Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function AGO1_HUMAN Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). See Also Argonaute 3D structures Eukaryotic initiation factor 3D structures

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