5cv3 | pdb_00005cv3

C. remanei PGL-1 Dimerization Domain - Hg

spinqualitylabelsall models 5cv3, resolution 3.17Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5cv3 is a 1 chain structure with sequence from Caenorhabditis remanei. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.1701477Å Ligands: EMC Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PGL1_CAERE Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate (PubMed:26787882). Essential role in male and female postembryonic germline development; maternally provided protein maintains a population of proliferating germ cells and zygotic expression is required for correct oogenesis (By similarity). Together with the P-granule component pgl-3, is involved in the formation of P-granules (By similarity). Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules (By similarity). In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis during normal oogenesis and development of the two gonadal arms (By similarity). This may in part be through regulating the localization of sir-2.1 which is involved in germ cell apoptosis (By similarity). May protect somatic cells from excessive apoptosis during normal development (By similarity).[UniProtKB:Q9TZQ3]

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