5cw5 | pdb_00005cw5

Structure of CfBRCC36-CfKIAA0157 complex (QSQ mutant)

spinqualitylabelsall models 5cw5, resolution 2.74Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5cw5 is a 4 chain structure with sequence from Camponotus floridanus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.736Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function BRCC3_CAMFO Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, leaving the last ubiquitin chain attached to its substrates. Catalytic subunit of the BRISC complex; does not have activity by itself, but needs to be associated into a heterotetramer with ABRAXAS2 for minimal in vitro activity (PubMed:26344097). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating spindle assembly factors (By similarity).[UniProtKB:Q15018][UniProtKB:Q3TCJ1]

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