5yew | pdb_00005yew

Structural basis for GTP hydrolysis and conformational change of mitofusin 1 in mediating mitochondrial fusion

spinqualitylabelsall models 5yew, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5yew is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.2Å Ligands: BEF, GDP, K, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MFN1_HUMAN Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.

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