8v08 | pdb_00008v08

Crystal structure of human PLD4 co-crystallized with 5'Pi-ssDNA

spinqualitylabelsall models 8v08, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8v08 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3Å Ligands: NEP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PLD4_HUMAN 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia.[UniProtKB:Q8BG07]

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