6n7x | pdb_00006n7x

S. cerevisiae U1 snRNP

Loading... Status: waiting for Mol* initialization Structural highlights 6n7x is a 10 chain structure with sequence from Saccharomyces cerevisiae S288C. This structure supersedes the now removed PDB entry 5uz5. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.6Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RU1C_YEAST Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. YHC1/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. See Also Nucleoprotein 3D structures

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