3uon | pdb_00003uon

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

spinqualitylabelsall models 3uon, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3uon is a 1 chain structure with sequence from Escherichia virus T4 and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3Å Ligands: BGC, CL, QNB Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease ACM2_HUMAN Disease susceptibility is associated with variations affecting the gene represented in this entry. Function ACM2_HUMAN The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.ENLYS_BPT4 Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer. See Also Lysozyme 3D structures Muscarinic acetylcholine receptor

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