3vdx | pdb_00003vdx

Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains

spinqualitylabelsall models 3vdx, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3vdx is a 3 chain structure with sequence from Influenza A virus (A/Puerto Rico/8/1934(H1N1)) and Kitasatospora aureofaciens. The September 2013 RCSB PDB Molecule of the Month feature on Designed Protein Cages by David Goodsell is 10.2210/rcsb_pdb/mom_2013_9. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.002Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function BPOA2_KITAU May be a chlorinating enzyme involved in 7-chlorotetracycline biosynthesis.M1_I34A1 Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place. Determines the virion's shape: spherical or filamentous. Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology. Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.

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