3deg | pdb_00003deg

Complex of elongating Escherichia coli 70S ribosome and EF4(LepA)-GMPPNP

Loading... Status: waiting for Mol* initialization Structural highlights 3deg is a 10 chain structure with sequence from Escherichia coli and Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 10.9Å Ligands: 1MA, 2MG, 5MC, 5MU, 7MG, H2U, M2G, OMC, OMG, PSU, YG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function LEPA_ECOLI Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Elongation factor 3D structures Escherichia coli LepA%2C the ribosomal back translocase GTP-binding protein 3D structures Ribosomal protein L11 3D structures Transfer RNA (tRNA)

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